Rabbit Polyclonal Antibody to SKP2 (Ab-64)
货号：
P41605
别名：
FBXL1
应用：
WB
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q13309
规格：
目录价
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Description |
|---|
Substrate recognition component of a SCF (SKP1-CUL1-F-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins involved in cell cycle progression, signal transduction and transcription. Specifically recognizes phosphorylated CDKN1B/p27kip and is involved in regulation of G1/S transition. Degradation of CDKN1B/p27kip also requires CKS1. Recognizes target proteins ORC1, CDT1, RBL2, KMT2A/MLL1, CDK9, RAG2, FOXO1, UBP43, and probably MYC, TOB1 and TAL1. Degradation of TAL1 also requires STUB1. Recognizes CDKN1A in association with CCNE1 or CCNE2 and CDK2. Promotes ubiquitination and destruction of CDH1 in a CK1-Dependent Manner, thereby regulating cell migration. |
References |
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| 1)Tedesco D., Lukas J., Reed S.I.Genes Dev. 16:2946-2957(2002) 2)Mendez J., Zou-Yang X.H., Kim S.Y., Hidaka M., Tansey W.P., Stillman B.Mol. Cell 9:481-491(2002) 3)Li X., Zhao Q., Liao R., Sun P., Wu X.J. Biol. Chem. 278:30854-30858(2003) |
Specification |
|
|---|---|
| Aliases | FBXL1 |
| Entrez GeneID | 6502; |
| Swissprot | Q13309 |
| WB Predicted band size | 48kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Peptide sequence around aa.62~66 (P-E-S-P-P) derived from Human SKP2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
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|---|---|
| WB | 1/500-1/1000 |
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