Rabbit Polyclonal Antibody to MMP8
货号:
P41626
别名:
matrix metallopeptidase 8 (neutrophil collagenase), HNC, CLG1, MMP-8, PMNL-CL
应用:
WB,IHC
反应种属:
Human
抗体类型:
Primary antibody
Swissprot:
P22894
规格:
目录价
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Description |
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Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMP's are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. However, the enzyme encoded by this gene is stored in secondary granules within neutrophils and is activated by autolytic cleavage. Its function is degradation of type I, II and III collagens. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. |
Specification |
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Aliases | matrix metallopeptidase 8 (neutrophil collagenase), HNC, CLG1, MMP-8, PMNL-CL |
Entrez GeneID | 4317; |
Swissprot | P22894 |
WB Predicted band size | 53kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Synthetic peptide corresponding to a region derived from 122-135 amino acids of human matrix metallopeptidase 8 (neutrophil collagenase) |
Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
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WB | 1/500-1/2000 |
IHC | 1/25-1/100 |
ELISA | 1:2000-1:5000 |
Product Image
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Gel: 8% SDS-PAGE Lysate: 40ug 231 cell lysate Primary antibody: 1/800 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/5000 dilution Exposure time: 10 seconds
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The image on the left is immunohistochemistry of paraffin-embedded Human colon cancer tissue using 31238 (MMP8 Antibody) at dilution 1/45, on the right is treated with the synthetic peptide.