Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function.Lothar Goretzki, AACR Meeting Abstracts, Apr 2006; 2006: 468.Jean-Fran?ois Louvion, Mol. Biol. Cell, Nov 1998; 9: 3071.Angelika Lueking, Mol. Cell. Proteomics, Dec 2003; 2: 1342.Jason Fontana Circ, Res., May 2002; 90: 866.