Rabbit Polyclonal Antibody to PIWIL4
货号：
P41617
别名：
Piwi-like RNA-mediated gene silencing 4, HIWI2; MIWI2
应用：
WB
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q7Z3Z4
规格：
目录价
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Description |
|---|
PIWIL4 belongs to the Argonaute family of proteins, which function in development and maintenance of germline stem cells. Plays a central role during spermatogenesis by repressing transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Directly binds piRNAs, a class of 24 to 30 nucleotide RNAs that are generated by a Dicer-independent mechanism and are primarily derived from transposons and other repeated sequence elements. Associates with secondary piRNAs antisense and PIWIL2/MILI is required for such association. |
Specification |
|
|---|---|
| Aliases | Piwi-like RNA-mediated gene silencing 4, HIWI2; MIWI2 |
| Entrez GeneID | 143689; |
| Swissprot | Q7Z3Z4 |
| WB Predicted band size | 97kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Fusion protein corresponding to a region derived from 546-838 amino acids of human piwi-like RNA-mediated gene silencing 4 |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/2000 |
| ELISA | 1:2000-1:5000 |
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