Rabbit Polyclonal Antibody to PLCG1 (Ab-771)
货号：
P41638
别名：
Phospholipase C gamma 1; PLC148; PHOSPHOLIPASE C-148;
应用：
WB,IHC
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
P19174
规格：
目录价
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Description |
|---|
Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. Becomes activated in response to ligand-mediated activation of receptor-type tyrosine kinases, such as PDGFRA, PDGFRB, FGFR1, FGFR2, FGFR3 and FGFR4. Plays a role in actin reorganization and cell migration.Denis Tvorogov, J. Cell Sci., Feb 2005; 118: 601 - 610.Brenda J. Irvin, Mol. Cell. Biol., Dec 2000; 20: 9149 - 9161.Benoit Poulin, J. Biol. Chem., Feb 2000; 275: 6411.Ichiro Nakamura, J. Cell Biol., Jan 2001; 152: 361. |
Specification |
|
|---|---|
| Aliases | Phospholipase C gamma 1; PLC148; PHOSPHOLIPASE C-148; |
| Entrez GeneID | 5335; |
| Swissprot | P19174 |
| WB Predicted band size | 150kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized non-phosphopeptide derived from human PLCG1 around the phosphorylation site of tyrosine 771 (P-D-Y-G-A). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/3000 |
| IHC | 1/50-1/100 |
Product Image
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Western blot analysis of extracts from COS7 cells treated with EGF (200ng/ml, 30min), using PLCG1 (Ab-771) antibody P41638.
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Western blot analysis of extracts from COS7 cells (Lane 2), and JK cells (Lane 3), using PLCG1 (Ab-771) antiobdy P41638. The lane on the left is treated with synthesized peptide.
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Immunohistochemical analysis of paraffin-embedded human breast carcinoma tissue using PLCG1 (Ab-771) antibody P41638.
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