Rabbit Polyclonal Antibody to MITF (Ab-180/73)
货号：
P41648
别名：
MITF M1; Microphthalmia-associated transcription factor;
应用：
WB,IHC,IF
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
O75030
规格：
目录价
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Description |
|---|
Transcription factor that regulates the expression of genes with essential roles in cell differentiation, proliferation and survival. Binds to symmetrical DNA sequences (E-boxes) (5'-CACGTG-3') found in the promoters of target genes, such as BCL2 and tyrosinase (TYR). Plays an important role in melanocyte development by regulating the expression of tyrosinase (TYR) and tyrosinase-related protein 1 (TYRP1). Plays a critical role in the differentiation of various cell types, such as neural crest-derived melanocytes, mast cells, osteoclasts and optic cup-derived retinal pigment epithelium.J篓庐n H. Hallsson, Genetics, May 2004; 167: 233 - 241. Eiichi Morii, Blood, Apr 2001; 97: 2038 - 2044. Eiichi Morii, Blood, Sep 2004; 104: 1656 - 1661. |
Specification |
|
|---|---|
| Aliases | MITF M1; Microphthalmia-associated transcription factor; |
| Entrez GeneID | 4286; |
| Swissprot | O75030 |
| WB Predicted band size | 52kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized non-phosphopeptide derived from human MITF around the phosphorylation site of serine 180/73 (P-N-S(p)-P-M). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/3000 |
| IHC | 1/50-1/100 |
| IF | 1/100-1/500 |
Product Image
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Western blot analysis of extracts from HepG2 cells (lane 1) and COLO205 cells (lane 2), using MITF (Ab-180/73) antibody P41648.
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Western blot analysis of extracts from HepG2 cells (Lane 2) and 3T3 cells (Lane 3), using MITF (Ab-180/73) antiobdy P41648. The lane on the left is treated with synthesized peptide.
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Immunofluorescence analysis of HeLa cells, using MITF (Ab-180/73) antibody P41648.
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Immunohistochemistry analysis of paraffin-embedded human skin tissue using MITF (Ab-180/73) antibody P41648.
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