Rabbit Polyclonal Antibody to SNAI1 (Ab-246)
货号：
P41686
别名：
SNAH; SNAI; Sna; Snail; zinc finger protein SNAI1
应用：
WB
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
O95863
规格：
目录价
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Description |
|---|
Involved in induction of the epithelial to mesenchymal transition (EMT), formation and maintenance of embryonic mesoderm, growth arrest, survival and cell migration. Binds to 3 E-boxes of the E-cadherin/CDH1 gene promoter and to the promoters of CLDN7 and KRT8 and, in association with histone demethylase KDM1A which it recruits to the promoters, causes a decrease in dimethylated H3K4 levels and represses transcription. Associates with EGR1 and SP1 to mediate tetradecanoyl phorbol acetate (TPA)-induced up-regulation of CDKN2B, possibly by binding to the CDKN2B promoter region 5'-TCACA-3. In addition, may also activate the CDKN2B promoter by itself.Okubo T., Cancer Res. 61:1338-1346(2001).Twigg S.R., Hum. Genet. 105:320-326(1999).Paznekas W.A., Genomics 62:42-49(1999) |
Specification |
|
|---|---|
| Aliases | SNAH; SNAI; Sna; Snail; zinc finger protein SNAI1 |
| Entrez GeneID | 6615; |
| Swissprot | O95863 |
| WB Predicted band size | 29kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized non-phosphopeptide derived from human SNAI1 around the phosphorylation site of serine 246 (T-F-S(p)-R-M). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/3000 |
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