Rabbit Polyclonal Antibody to Smad2 (Ab-220)
货号：
P41668
别名：
JV18-1; MADH2; MADR2; Mad-related protein 2; Mothers against DPP homolog 2
应用：
WB,IHC
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q15796
规格：
目录价
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Description |
|---|
Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.Riggins G.J., Nat. Genet. 13:347-349(1996).Zhang Y., Nature 383:168-172(1996).Eppert K., Cell 86:543-552(1996). |
Specification |
|
|---|---|
| Aliases | JV18-1; MADH2; MADR2; Mad-related protein 2; Mothers against DPP homolog 2 |
| Entrez GeneID | 4087; |
| Swissprot | Q15796 |
| WB Predicted band size | 60kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized non-phosphopeptide derived from human Smad2 around the phosphorylation site of threonine 220 (P-E-T(p)-P-P). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/3000 |
| IHC | 1/50-1/100 |
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