Rabbit Polyclonal Antibody to AurB/C (Ab-202/175)
货号：
P41681
别名：
AIE1; AIE2; AURKC; Aurora-C; Aurora/Ipl1-related kinase 3
应用：
WB
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q9UQB9
规格：
目录价
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Description |
|---|
Serine/threonine-protein kinase component of the chromosomal passenger complex (CPC), a complex that acts as a key regulator of mitosis. The CPC complex has essential functions at the centromere in ensuring correct chromosome alignment and segregation and is required for chromatin-induced microtubule stabilization and spindle assembly. Plays also a role in meiosis and more particularly in spermatogenesis. Has redundant cellular functions with AURKB and can rescue an AURKB knockdown. Like AURKB, AURKC phosphorylates histone H3 at 'Ser-10' and 'Ser-28'. Phosphorylates TACC1, another protein involved in cell division, at 'Ser-228' |
References |
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| Tseng T.-C., DNA Cell Biol. 17:823-833(1998) Bernard M., Genomics 53:406-409(1998) Kimura M., J. Biol. Chem. 274:7334-7340(1999) |
Specification |
|
|---|---|
| Aliases | AIE1; AIE2; AURKC; Aurora-C; Aurora/Ipl1-related kinase 3 |
| Entrez GeneID | 6795; |
| Swissprot | Q9UQB9 |
| WB Predicted band size | 39kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized non-phosphopeptide derived from human AurB/C around the phosphorylation site of threonine 202/175 (C-G-T(p)-L-D). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/3000 |
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