Rabbit Polyclonal Antibody to PAK3 (Ab-154)
货号：
P41723
别名：
beta-PAK; CDC42/RAC effector kinase PAK-B; EC 2.7.1.; EC 2.7.11.1; kinase PAK3
应用：
WB
反应种属：
Human,Rat
抗体类型：
Primary antibody
Swissprot：
O75914
规格：
目录价
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Description |
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Serine/threonine protein kinase that plays a role in a variety of different signaling pathways including cytoskeleton regulation, cell migration, or cell cycle regulation. Plays a role in dendrite spine morphogenesis as well as synapse formation and plasticity. Acts as downstream effector of the small GTPases CDC42 and RAC1. Activation by the binding of active CDC42 and RAC1 results in a conformational change and a subsequent autophosphorylation on several serine and/or threonine residues. Phosphorylates MAPK4 and MAPK6 and activates the downstream target MAPKAPK5, a regulator of F-actin polymerization and cell migration. Additionally, phosphorylates TNNI3/troponin I to modulate calcium sensitivity and relaxation kinetics of thin myofilaments. May also be involved in early neuronal development.Allen K.M., Nat. Genet. 20:25-30(1998).Jiang C., Submitted (MAY-2000) to the EMBL/GenBank/DDBJ databases.Kitano T., Mol. Biol. Evol. 20:1281-1289(2003). |
Specification |
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|---|---|
| Aliases | beta-PAK; CDC42/RAC effector kinase PAK-B; EC 2.7.1.; EC 2.7.11.1; kinase PAK3 |
| Entrez GeneID | 5063; |
| Swissprot | O75914 |
| WB Predicted band size | 72kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Rat |
| Immunogen | Synthesized non-phosphopeptide derived from human PAK3 around the phosphorylation site of serine 154 (Y-M-S(p)-F-T). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
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|---|---|
| WB | 1/500-1/3000 |
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