Rabbit Polyclonal Antibody to IRS-1 (Ab-312)
货号：
P41692
别名：
Insulin receptor substrate-1; IRS-1; IRS1;
应用：
WB,IHC,IF
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
P35568
规格：
目录价
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Description |
|---|
May mediate the control of various cellular processes by insulin. When phosphorylated by the insulin receptor binds specifically to various cellular proteins containing SH2 domains such as phosphatidylinositol 3-kinase p85 subunit or GRB2. Activates phosphatidylinositol 3-kinase when bound to the regulatory p85 subunit By similarity.Araki E., Diabetes 42:1041-1054(1993).Nishiyama M., Biochem. Biophys. Res. Commun. 183:280-285(1992).The MGC Project Team; Genome Res. 14:2121-2127(2004) |
Specification |
|
|---|---|
| Aliases | Insulin receptor substrate-1; IRS-1; IRS1; |
| Entrez GeneID | 3667; |
| Swissprot | P35568 |
| WB Predicted band size | 180kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized non-phosphopeptide derived from human IRS-1 around the phosphorylation site of serine 312 (A-T-S(p)-P-A). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/3000 |
| IHC | 1/50-1/100 |
| IF | 1/100-1/500 |
Product Image
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Western blot analysis of extracts from NIH-3T3 cells, using IRS-1 (Ab-312) antibody P41692.
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Western blot analysis of extracts from JK cells (Lane 2), using IRS-1 (Ab-312) antiobdy P41692. The lane on the left is treated with synthesized peptide.
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Immunofluorescence analysis of HeLa cells, using IRS-1 (Ab-312) antibody P41692.
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Immunohistochemistry analysis of paraffin-embedded human breast carcinoma tissue, using IRS-1 (Ab-312) antibody P41692.
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