Rabbit Polyclonal Antibody to PEK/PERK (Ab-981)
货号：
P41724
别名：
E2AK3; EC 2.7.11.1; EIF2AK3; Eukaryotic translation initiation factor 2-alpha kinase 3 precursor; HsPEK
应用：
WB,IHC,IF
反应种属：
Human,Mouse,Rat
抗体类型：
Primary antibody
Swissprot：
Q9NZJ5
规格：
目录价
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Description |
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Phosphorylates the alpha subunit of eukaryotic translation-initiation factor 2 (EIF2), leading to its inactivation and thus to a rapid reduction of translational initiation and repression of global protein synthesis. Serves as a critical effector of unfolded protein response (UPR)-induced G1 growth arrest due to the loss of cyclin-D1 (CCND1) By similarity |
References |
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| Shi Y., J. Biol. Chem. 274:5723-5730(1999) Sood R., Biochem. J. 346:281-293(2000) Delepine M., Nat. Genet. 25-406-409(2000). |
Specification |
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|---|---|
| Aliases | E2AK3; EC 2.7.11.1; EIF2AK3; Eukaryotic translation initiation factor 2-alpha kinase 3 precursor; HsPEK |
| Entrez GeneID | 9451; |
| Swissprot | Q9NZJ5 |
| WB Predicted band size | 125kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse,Rat |
| Immunogen | Synthesized non-phosphopeptide derived from human PEK/PERK around the phosphorylation site of threonine 981 (R-H-T(p)-G-Q). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/3000 |
| IHC | 1/50-1/100 |
| IF | 1/100-1/500 |
| ELISA | 1:20000-1:40000 |
Product Image
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Western blot analysis of extracts from MCF-7 cells, using PEK/PERK (Ab-981) antibody P41724.
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Western blot analysis of extracts from JK cells (Lane 2), using PEK/PERK (Ab-981) antiobdy P41724. The lane on the left is treated with synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human colon carcinoma tissue using PEK/PERK (Ab-981) antibody P41724.
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