Rabbit Polyclonal Antibody to APLF (Ab-116)
货号：
P41744
别名：
APFL; aprataxin and PNK-like factor; C2orf13; Xip1;
应用：
WB,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q8IW19
规格：
目录价
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Description |
|---|
Nuclease involved in single-strand and double-strand DNA break repair. Recruited to sites of DNA damage through interaction with poly(ADP-ribose), a polymeric post-translational modification synthesized transiently at sites of chromosomal damage to accelerate DNA strand break repair reactions. Displays apurinic-apyrimidinic (AP) endonuclease and 3'-5' exonuclease activities in vitro. Also able to introduce nicks at hydroxyuracil and other types of pyrimidine base damage.Saunders W.S., J. Cell Sci. 104:573-582(1993).Ye Q., J. Biol. Chem. 271:14653-14656(1996).Ye Q., J. Biol. Chem. 272:14983-14989(1997). |
Specification |
|
|---|---|
| Aliases | APFL; aprataxin and PNK-like factor; C2orf13; Xip1; |
| Entrez GeneID | 200558; |
| Swissprot | Q8IW19 |
| WB Predicted band size | 57kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized non-phosphopeptide derived from human APLF around the phosphorylation site of serine 116 (R-N-S(p)-Q-V). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/3000 |
| IHC | 1/50-1/100 |
Product Image
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Western blot analysis of extracts from HT-29 cells, using APLF (Ab-116) antibody P41744.
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Western blot analysis of extracts from COS7 cells (Lane 2), using APLF (Ab-116) antiobdy P41744. The lane on the left is treated with systhesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human brain tissue using APLF (Ab-116) antibody P41744.
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