Rabbit Polyclonal Antibody to CNOT2 (Ab-101)
货号：
P41761
别名：
CCR4-associated factor 2; CCR4-NOT transcription complex subunit 2; CCR4-NOT transcription complex; subunit 2; CDC36
应用：
WB
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q9NZN8
规格：
目录价
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Description |
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Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. Required for the CCR4-NOT complex structural integrity. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may specificly involve the N-Cor repressor complex containing HDAC3, NCOR1 and NCOR2. Involved in the maintenance of emryonic stem (ES) cell identity.Albert T.K., Nucleic Acids Res. 28:809-817(2000).Zhang Q.-H., Genome Res. 10:1546-1560(2000).Ota T., Nat. Genet. 36:40-45(2004). |
Specification |
|
|---|---|
| Aliases | CCR4-associated factor 2; CCR4-NOT transcription complex subunit 2; CCR4-NOT transcription complex; subunit 2; CDC36 |
| Entrez GeneID | 4848; |
| Swissprot | Q9NZN8 |
| WB Predicted band size | 46kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized non-phosphopeptide derived from human CNOT2 around the phosphorylation site of serine 101 (S-L-S(p)-Q-G). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
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|---|---|
| WB | 1/500-1/3000 |
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