Rabbit Polyclonal Antibody to HP1 alpha (Ab-92)
货号：
P41740
别名：
antigen p25; chromobox protein homolog 5; heterochromatin protein 1 alpha; HP1 alpha; HP1A
应用：
WB,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P45973
规格：
目录价
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Description |
|---|
Component of heterochromatin that recognizes and binds histone H3 tails methylated at 'Lys-9' (H3K9me), leading to epigenetic repression. In contrast, it is excluded from chromatin when 'Tyr-41' of histone H3 is phosphorylated (H3Y41ph). Can interact with lamin-B receptor (LBR). This interaction can contribute to the association of the heterochromatin with the inner nuclear membrane. Involved in the formation of functional kinetochore through interaction with MIS12 complex proteins.Saunders W.S., J. Cell Sci. 104:573-582(1993).The MGC Project Team; Genome Res. 14:2121-2127(2004).Ye Q., J. Biol. Chem. 271:14653-14656(1996). |
Specification |
|
|---|---|
| Aliases | antigen p25; chromobox protein homolog 5; heterochromatin protein 1 alpha; HP1 alpha; HP1A |
| Entrez GeneID | 23468; |
| Swissprot | P45973 |
| WB Predicted band size | 24kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized non-phosphopeptide derived from human HP1 alpha around the phosphorylation site of serine 92 (R-K-S(p)-N-F). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/3000 |
| IHC | 1/50-1/100 |
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