Rabbit Polyclonal Antibody to Cyclin D2 (Ab-280)
货号：
P41754
别名：
cyclin D2; G1/S-specific cyclin D2;
应用：
WB
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P30279
规格：
目录价
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Description |
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Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G1/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G1 phase. Hypophosphorylates RB1 in early G1 phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex By similarity.Xiong Y., Genomics 13:575-584(1992).Palmero I., Oncogene 8:1049-1054(1993).Kalnine N., Submitted (OCT-2004) to the EMBL/GenBank/DDBJ databases. |
Specification |
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|---|---|
| Aliases | cyclin D2; G1/S-specific cyclin D2; |
| Entrez GeneID | 894; |
| Swissprot | P30279 |
| WB Predicted band size | 42kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized non-phosphopeptide derived from human Cyclin D2 around the phosphorylation site of threonine 280 (A-S-T(p)-P-T). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
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|---|---|
| WB | 1/500-1/3000 |
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