Rabbit Polyclonal Antibody to Cyclin C (Ab-275)
货号：
P41753
别名：
The antiserum was produced against synthesized peptide derived from human Cyclin C.;
应用：
WB
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
P24863
规格：
目录价
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Description |
|---|
Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.Lew D.J., Cell 66:1197-1206(1991).Li H., Genomics 32:253-259(1996).Mungall A.J., Nature 425:805-811(2003). |
Specification |
|
|---|---|
| Aliases | The antiserum was produced against synthesized peptide derived from human Cyclin C.; |
| Entrez GeneID | 892; |
| Swissprot | P24863 |
| WB Predicted band size | 42kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized non-phosphopeptide derived from human Cyclin C around the phosphorylation site of serine 275 (N-G-S(p)-Q-N). |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/3000 |
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