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Rabbit Polyclonal Antibody to BL-CAM (Ab-807)
货号: P41734
别名: B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; Leu-14; Siglec-2
应用: WB
反应种属: Human
抗体类型: Primary antibody
Swissprot: P20273
规格:
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Description

Mediates B-cell B-cell interactions. May be involved in the localization of B-cells in lymphoid tissues. Binds sialylated glycoproteins; one of which is CD45. Preferentially binds to alpha-2,6-linked sialic acid. The sialic acid recognition site can be masked by cis interactions with sialic acids on the same cell surface. Upon ligand induced tyrosine phosphorylation in the immune response seems to be involved in regulation of B-cell antigen receptor signaling. Plays a role in positive regulation through interaction with Src family tyrosine kinases and may also act as an inhibitory receptor by recruiting cytoplasmic phosphatases via their SH2 domains that block signal transduction through dephosphorylation of signaling molecules.Wilson G.L., J. Exp. Med. 173:137-146(1991).Wilson G.L., J. Immunol. 150:5013-5024(1993).Stamenkovic I., Nature 345:74-77(1990).

Specification

Aliases B-cell receptor CD22; B-lymphocyte cell adhesion molecule; BL-CAM; Leu-14; Siglec-2
Entrez GeneID 933;
Swissprot P20273
WB Predicted band size 90kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Synthesized non-phosphopeptide derived from human BL-CAM around the phosphorylation site of tyrosine 807 (G-D-Y(p)-E-N).
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/3000
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