Rabbit Polyclonal Antibody to Collagen IV
货号：
P41792
别名：
COL4A1 NC1 domain; COLLAGEN OF BASEMENT MEMBRANE; ALPHA-1 CHAIN ARRESTEN; alpha 1 type IV collagen preproprotein; collagen IV alpha-1 polypeptide
应用：
WB,IHC,IF
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
P02462
规格：
目录价
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Description |
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Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen. Arresten, comprising the C-terminal NC1 domain, inhibits angiogenesis and tumor formation. The C-terminal half is found to possess the anti-angiogenic activity. Specifically inhibits endothelial cell proliferation, migration and tube formation. Inhibits expression of hypoxia-inducible factor 1alpha and ERK1/2 and p38 MAPK activation. Ligand for alpha1/beta1 integrin |
References |
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| Mary K. Chelberg, Cancer Res., Sep 1989; 49: 4796 - 4802 Patricia L. Graham, J. Cell Biol., Jun 1997; 137: 1171 PJ Lein, J. Cell Biol., Apr 1991; 113: 417 EC Tsilibary, J. Biol. Chem., Dec 1988; 263: 19112 - 19118. |
Specification |
|
|---|---|
| Aliases | COL4A1 NC1 domain; COLLAGEN OF BASEMENT MEMBRANE; ALPHA-1 CHAIN ARRESTEN; alpha 1 type IV collagen preproprotein; collagen IV alpha-1 polypeptide |
| Entrez GeneID | 1282; |
| Swissprot | P02462 |
| WB Predicted band size | 160kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from human Collagen IV. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/3000 |
| IHC | 1/50-1/100 |
| IF | 1/100-1/500 |
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