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Rabbit Polyclonal Antibody to CTRO
货号: P41859
别名: Citron Rho-interacting kinase; CRIK; Rho-interacting; serine/threonine-protein kinase 21; CIT
应用: IHC
反应种属: Human
抗体类型: Primary antibody
Swissprot: O14578
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Description

Plays a role in cytokinesis. Required for KIF14 localization to the central spindle and midbody. Putative RHO/RAC effector that binds to the GTP-bound forms of RHO and RAC1. It probably binds p21 with a tighter specificity in vivo. Dual specificity protein kinase activity catalyzing autophosphorylation and phosphorylation of exogenous substrates on both serine/threonine and tyrosine residues. Plays an important role in the regulation of cytokinesis and the development of the central nervous system. Phosphorylates MYL9/MLC2.Nagase T., DNA Res. 6:63-70(1999).Scherer S.E., Nature 440:346-351(2006).Gruneberg U., J. Cell Biol. 172:363-372(2006).

Specification

Aliases Citron Rho-interacting kinase; CRIK; Rho-interacting; serine/threonine-protein kinase 21; CIT
Entrez GeneID 11113;
Swissprot O14578
WB Predicted band size 231kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Synthesized peptide derived from internal of human CTRO.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

IHC 1/50-1/100
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