Rabbit Polyclonal Antibody to PIAS4
货号：
P41842
别名：
PIAS-gamma; PIASG; PIASy; protein inhibitor of activated STAT protein 4; protein inhibitor of activated STAT protein PIASy
应用：
WB,IHC
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
Q8N2W9
规格：
目录价
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Description |
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Functions as an E3-type small ubiquitin-like modifier (SUMO) ligase, stabilizing the interaction between UBE2I and the substrate, and as a SUMO-tethering factor. Plays a crucial role as a transcriptional coregulation in various cellular pathways, including the STAT pathway, the p53/TP53 pathway, the Wnt pathway and the steroid hormone signaling pathway. Involved in gene silencing. Mediates sumoylation of CEBPA, PARK7, HERC2, MYB, TCF4 and RNF168. In Wnt signaling, represses LEF1 and enhances TCF4 transcriptional activities through promoting their sumoylations.Zendra E. Zehner, AACR Meeting Abstracts, Apr 2005; 2005: 456. Amador Albor, J. Biol. Chem., Sep 2006; 281: 25850 - 25866. Christina-Maria Hecker, J. Biol. Chem., Jun 2006; 281: 16117 - 16127. Yun Zhao, Stem Cells, Apr 2007; 10.1634. |
Specification |
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|---|---|
| Aliases | PIAS-gamma; PIASG; PIASy; protein inhibitor of activated STAT protein 4; protein inhibitor of activated STAT protein PIASy |
| Entrez GeneID | 51588; |
| Swissprot | Q8N2W9 |
| WB Predicted band size | 56kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from Internal of human PIAS4. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
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|---|---|
| WB | 1/500-1/3000 |
| IHC | 1/50-1/100 |
Product Image
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Western blot analysis of extracts from Jurkat cells, using PIAS4 antibody P41842.
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Western blot analysis of extracts from JK cells (Lane 2), using PIAS4 antiobdy P41842. The lane on the left is treated with synthesized peptide.
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Immunohistochemistry analysis of paraffin-embedded human lung carcinoma tissue using PIAS4 antibody P41842.
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