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Rabbit Polyclonal Antibody to NR2F6
货号: P41904
别名: EAR2; ERBAL2; NR2F6; Orphan nuclear receptor EAR-2; V-erbA related protein EAR-2
应用: WB,IHC,IF
反应种属: Human,Mouse,Rat
抗体类型: Primary antibody
Swissprot: P10588
规格:
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Description

Transcription factor predominantly involved in transcriptional repression. Binds to promoter/enhancer response elements that contain the imperfect 5'-AGGTCA-3' direct or inverted repeats with various spacings which are also recognized by other nuclear hormone receptors. Involved in modulation of hormonal responses. Represses transcriptional activity of the lutropin-choriogonadotropic hormone receptor/LHCGR gene, the renin/REN gene and the oxytocin-neurophysin/OXT gene. Represses the triiodothyronine-dependent and -independent transcriptional activity of the thyroid hormone receptor gene in a cell type-specific manner. The corepressing function towards thyroid hormone receptor beta/THRB involves at least in part the inhibition of THRB binding to triiodothyronine response elements (TREs) by NR2F6. Inhibits NFATC transcription factor DNA binding and subsequently its transcriptional activity. Acts as transcriptional repressor of IL-17 expression in Th-17 differentiated CD4+ T cells and may be involved in induction and/or maintenance of peripheral immunological tolerance and autoimmunity. Involved in development of forebrain circadian clock; is required early in the development of the locus coeruleus (LC).Miyajima N., Nucleic Acids Res. 16:11057-11074(1988).The MGC Project Team, Genome Res. 14:2121-2127(2004).Beausoleil S.A., Proc. Natl. Acad. Sci. U.S.A. 101:12130-12135(2004).

Specification

Aliases EAR2; ERBAL2; NR2F6; Orphan nuclear receptor EAR-2; V-erbA related protein EAR-2
Entrez GeneID 2063;
Swissprot P10588
WB Predicted band size 42kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse,Rat
Immunogen Synthesized peptide derived from N-terminal of human NR2F6.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/3000
IHC 1/50-1/100
IF 1/100-1/500
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