Rabbit Polyclonal Antibody to KSR2
货号：
P42028
别名：
hKSR2; Kinase suppressor of Ras 2; KSR2;
应用：
WB,IF
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
Q6VAB6
规格：
目录价
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Description |
|---|
Location-regulated scaffold connecting MEK to RAF. Has very low protein kinase activity and can phosphorylate MAP2K1 at several Ser and Thr residues with very low efficiency (in vitro). Interaction with BRAF enhances KSR2-mediated phosphorylation of MAP2K1 (in vitro). Blocks MAP3K8 kinase activity and MAP3K8-mediated signaling. Acts as a negative regulator of MAP3K3-mediated activation of ERK, JNK and NF-kappa-B pathways, inhibiting MAP3K3-mediated interleukin-8 production |
References |
|---|
| Ota T., Nat. Genet. 36:40-45(2004) Scherer S.E., Nature 440:346-351(2006) Channavajhala P.L., J. Biol. Chem. 278:47089-47097(2003). |
Specification |
|
|---|---|
| Aliases | hKSR2; Kinase suppressor of Ras 2; KSR2; |
| Entrez GeneID | 283455; |
| Swissprot | Q6VAB6 |
| WB Predicted band size | 108kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human KSR2. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/3000 |
| IF | 1/100-1/500 |
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