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Mouse Monoclonal Antibody to MYC
货号: 31843
别名: MRTL; MYCC; c-Myc; bHLHe39
应用: FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: P01106
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Description

This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini.

References

1.J Exp Clin Cancer Res. 2018 Sep 27;37(1):239.
2.Am J Surg Pathol. 2018 Nov;42(11):1488-1494.

Specification

Aliases MRTL; MYCC; c-Myc; bHLHe39
Entrez GeneID 4609
Swissprot P01106
clone 3D1E12
WB Predicted band size 48.8kDa
Host/Isotype Mouse IgG2b
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Synthesized peptide of human MYC (AA: 23-37)
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

FCM 1/200 - 1/400
ELISA 1/10000
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