Mouse Monoclonal Antibody to MYC
货号:
31843
别名:
MRTL; MYCC; c-Myc; bHLHe39
应用:
FCM
反应种属:
Human
抗体类型:
Primary antibody
Swissprot:
P01106
规格:
目录价
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Description |
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This gene is a proto-oncogene and encodes a nuclear phosphoprotein that plays a role in cell cycle progression, apoptosis and cellular transformation. The encoded protein forms a heterodimer with the related transcription factor MAX. This complex binds to the E box DNA consensus sequence and regulates the transcription of specific target genes. Amplification of this gene is frequently observed in numerous human cancers. Translocations involving this gene are associated with Burkitt lymphoma and multiple myeloma in human patients. There is evidence to show that translation initiates both from an upstream, in-frame non-AUG (CUG) and a downstream AUG start site, resulting in the production of two isoforms with distinct N-termini. |
References |
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1.J Exp Clin Cancer Res. 2018 Sep 27;37(1):239. 2.Am J Surg Pathol. 2018 Nov;42(11):1488-1494. |
Specification |
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Aliases | MRTL; MYCC; c-Myc; bHLHe39 |
Entrez GeneID | 4609 |
Swissprot | P01106 |
clone | 3D1E12 |
WB Predicted band size | 48.8kDa |
Host/Isotype | Mouse IgG2b |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Synthesized peptide of human MYC (AA: 23-37) |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application |
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FCM | 1/200 - 1/400 |
ELISA | 1/10000 |