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Rabbit Polyclonal Antibody to CLK4
货号: P42111
别名: Dual specificity protein kinase CLK4; EC 2.7.12.1; CDC-like kinase 4; CLK4;
应用: WB
反应种属: Human,Mouse
抗体类型: Primary antibody
Swissprot: Q9HAZ1
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Description

Dual specificity kinase acting on both serine/threonine and tyrosine-containing substrates. Phosphorylates serine- and arginine-rich (SR) proteins of the spliceosomal complex and may be a constituent of a network of regulatory mechanisms that enable SR proteins to control RNA splicing. Phosphorylates SRSF1 and SRSF3. Required for the regulation of alternative splicing of MAPT/TAU. Regulates the alternative splicing of tissue factor (F3) pre-mRNA in endothelial cells.Schultz J., Genomics 71:368-370(2001).McNally T., Protein Sci. 12:1562-1566(2003).Kantham L., Biochem. Biophys. Res. Commun. 304:125-129(2003).

Specification

Aliases Dual specificity protein kinase CLK4; EC 2.7.12.1; CDC-like kinase 4; CLK4;
Entrez GeneID 57396;
Swissprot Q9HAZ1
WB Predicted band size 65kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse
Immunogen Synthesized peptide derived from internal of human CLK4.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/3000
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