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Mouse Monoclonal Antibody to SDHB
货号: 31841
别名: IP; SDH; CWS2; PGL4; SDH1; SDH2; SDHIP
应用: IHC,FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: P21912
规格:
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Description

Complex II of the respiratory chain, which is specifically involved in the oxidation of succinate, carries electrons from FADH to CoQ. The complex is composed of four nuclear-encoded subunits and is localized in the mitochondrial inner membrane. The iron-sulfur subunit is highly conserved and contains three cysteine-rich clusters which may comprise the iron-sulfur centers of the enzyme. Sporadic and familial mutations in this gene result in paragangliomas and pheochromocytoma, and support a link between mitochondrial dysfunction and tumorigenesis.

References

1.Endocrine. 2017 Sep;57(3):512-517.
2.J Natl Cancer Inst. 2016 Jan;108(1).

Specification

Aliases IP; SDH; CWS2; PGL4; SDH1; SDH2; SDHIP
Entrez GeneID 6390
Swissprot P21912
clone 2B2B1
WB Predicted band size 31.6kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human SDHB (AA: 29-280) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

IHC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
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