Rabbit Polyclonal Antibody to BCOR
货号：
P42166
别名：
BCL-6 corepressor; BCoR; BCOR; KIAA1575;
应用：
WB,IHC
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
Q6W2J9
规格：
目录价
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Description |
|---|
Transcriptional corepressor. May specifically inhibit gene expression when recruited to promoter regions by sequence-specific DNA-binding proteins such as BCL6 and MLLT3. This repression may be mediated at least in part by histone deacetylase activities which can associate with this corepressor. Involved in the repression of TFAP2A; impairs binding of BCL6 and KDM2B to TFAP2A promoter regions. Via repression of TFAP2A acts as a negative regulator of osteo-dentiogenic capacity in adult stem cells; the function implies inhibition of methylation on histone H3 'Lys-4' (H3K4me3) and 'Lys-36' (H3K36me2).Huynh K.D., Genes Dev. 14:1810-1823(2000).Ng D., Nat. Genet. 36:411-416(2004).Nagase T., DNA Res. 7:273-281(2000). |
Specification |
|
|---|---|
| Aliases | BCL-6 corepressor; BCoR; BCOR; KIAA1575; |
| Entrez GeneID | 54880; |
| Swissprot | Q6W2J9 |
| WB Predicted band size | 192kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Synthesized peptide derived from internal of human BCOR. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/3000 |
| IHC | 1/50-1/100 |
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