Rabbit Polyclonal Antibody to BARD1
货号：
P42203
别名：
BRCA1-associated RING domain protein 1; BARD-1; BARD1;
应用：
WB
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q99728
规格：
目录价
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Description |
|---|
Probable E3 ubiquitin-protein ligase. The BRCA1-BARD1 heterodimer specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Plays a central role in the control of the cell cycle in response to DNA damage. Acts by mediating ubiquitin E3 ligase activity that is required for its tumor suppressor function. Also forms a heterodimer with CSTF1/CSTF-50 to modulate mRNA processing and RNAP II stability by inhibiting pre-mRNA 3' cleavage.Wu L.C., Nat. Genet. 14:430-440(1996).Thai T.H., Hum. Mol. Genet. 7:195-202(1998).Hillier L.W., Nature 434:724-731(2005). |
Specification |
|
|---|---|
| Aliases | BRCA1-associated RING domain protein 1; BARD-1; BARD1; |
| Entrez GeneID | 580; |
| Swissprot | Q99728 |
| WB Predicted band size | 79kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from N-terminal of human BARD1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/3000 |
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