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Rabbit Polyclonal Antibody to RPC2
货号: P42390
别名: DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide; EC 2.7.7.6; polymerase (RNA) III (DNA directed) polypeptide B; RNA polymerase III subunit 2; RNA polymerase III subunit RPC2
应用: WB
反应种属: Human,Mouse
抗体类型: Primary antibody
Swissprot: Q9NW08
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Description

DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol III is composed of mobile elements and RPC2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft By similarity. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway.Hu P., Mol. Cell. Biol. 22:8044-8055(2002).The MGC Project Team; Genome Res. 14:2121-2127(2004).Ota T., Nat. Genet. 36:40-45(2004).

Specification

Aliases DNA-directed RNA polymerase III subunit 127.6 kDa polypeptide; EC 2.7.7.6; polymerase (RNA) III (DNA directed) polypeptide B; RNA polymerase III subunit 2; RNA polymerase III subunit RPC2
Entrez GeneID 55703;
Swissprot Q9NW08
WB Predicted band size 128kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse
Immunogen Synthesized peptide derived from internal of human RPC2.
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/3000
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