Rabbit Polyclonal Antibody to ARHGEF1
货号：
P42568
别名：
p115-RhoGEF; p115RhoGEF; 115 kDa guanine nucleotide exchange factor; Sub1.5;
应用：
WB
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q92888
规格：
目录价
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Description |
|---|
Seems to play a role in the regulation of RhoA GTPase by guanine nucleotide-binding alpha-12 (GNA12) and alpha-13 (GNA13) subunits. Acts as GTPase-activating protein (GAP) for GNA12 and GNA13, and as guanine nucleotide exchange factor (GEF) for RhoA GTPase. Activated G alpha 13/GNA13 stimulates the RhoGEF activity through interaction with the RGS-like domain. This GEF activity is inhibited by binding to activated GNA12. Mediates angiotensin-2-induced RhoA activation.Farmer A., Submitted (MAY-2003).Wedegaertner P.B., J. Biol. Chem. 275:14992-14999(2000).Han D.K., Sci. Signal. 2:RA46-RA46(2009). |
Specification |
|
|---|---|
| Aliases | p115-RhoGEF; p115RhoGEF; 115 kDa guanine nucleotide exchange factor; Sub1.5; |
| Entrez GeneID | 9138; |
| Swissprot | Q92888 |
| WB Predicted band size | 105kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human ARHGEF1. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
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|---|---|
| WB | 1/500-1/3000 |
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