Rabbit Polyclonal Antibody to STK36
货号：
P42590
别名：
Serine/threonine-protein kinase 36 EC 2.7.11.1; Fused homolog STK36;
应用：
WB,IHC
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
Q9NRP7
规格：
目录价
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Description |
|---|
Serine/threonine protein kinase which plays an important role in the sonic hedgehog (Shh) pathway by regulating the activity of GLI transcription factors. Controls the activity of the transcriptional regulators GLI1, GLI2 and GLI3 by opposing the effect of SUFU and promoting their nuclear localization. GLI2 requires an additional function of STK36 to become transcriptionally active, but the enzyme does not need to possess an active kinase catalytic site for this to occur. Required for postnatal development, possibly by regulating the homeostasis of cerebral spinal fluid or ciliary function. Essential for construction of the central pair apparatus of motile cilia.Murone M., Nat. Cell Biol. 2:310-312(2000).Nagase T., DNA Res. 6:337-345(1999).Hillier L.W., Nature 434:724-731(2005). |
Specification |
|
|---|---|
| Aliases | Serine/threonine-protein kinase 36 EC 2.7.11.1; Fused homolog STK36; |
| Entrez GeneID | 27148; |
| Swissprot | Q9NRP7 |
| WB Predicted band size | 170kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Synthesized peptide derived from internal of human STK36. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| WB | 1/500-1/3000 |
| IHC | 1/50-1/100 |
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