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Rabbit Polyclonal Antibody to PLA2G4A
货号: P42819
别名: PLA2G4; cPLA2-alpha
应用: WB,IHC
反应种属: Human
抗体类型: Primary antibody
Swissprot: P47712
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Description

This gene encodes a member of the cytosolic phospholipase A2 group IV family. The enzyme catalyzes the hydrolysis of membrane phospholipids to release arachidonic acid which is subsequently metabolized into eicosanoids. Eicosanoids, including prostaglandins and leukotrienes, are lipid-based cellular hormones that regulate hemodynamics, inflammatory responses, and other intracellular pathways. The hydrolysis reaction also produces lysophospholipids that are converted into platelet-activating factor. The enzyme is activated by increased intracellular Ca(2+) levels and phosphorylation, resulting in its translocation from the cytosol and nucleus to perinuclear membrane vesicles.

Specification

Aliases PLA2G4; cPLA2-alpha
Entrez GeneID 5321;
Swissprot P47712
WB Predicted band size 85kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Fusion protein corresponding to residues near the N terminal of human phospholipase A2, group IVA (cytosolic, calcium-dependent)
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/2000
IHC 1/50-1/200
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