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Rabbit Polyclonal Antibody to KDM4D
货号: P42827
别名: JMJD2D
应用: WB,IHC
反应种属: Human
抗体类型: Primary antibody
Swissprot: Q6B0I6
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Description

JMJD2D (Jumonji domain-containing protein 2D), also known as JHDM3D or KDM4D, is a 520 amino acid protein that belongs to the JHDM3 histone demethylase family. Localized to the nucleus, JMJD2D functions as a histone demethylase that removes specific methyl residues from Histone H3, thereby playing a crucial role in the histone code. JMJD2D binds iron as a cofactor and contains one JMJC domain and one JMJN domain, both of which are thought to exhibit enzymatic activity during chromatin remodeling events. In addition, JMJD2D forms a complex with the ligand-bound form of the androgen receptor (AR) and, through this interaction, activates AR expression. Overexpression of AR is associated with prostate cancer, suggesting that, via its ability to upregulate AR, JMJD2D may be involved in carcinogenesis.

Specification

Aliases JMJD2D
Entrez GeneID 55693;
Swissprot Q6B0I6
WB Predicted band size 59kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Fusion protein corresponding to a region derived from internal residues of human lysine (K)-specific demethylase 4D
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/500-1/2000
IHC 1/50-1/200
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