Mouse Monoclonal Antibody to PARP Mouse
货号：
P42970
别名：
COBA2; COL11A2; Collagen alpha-2(XI) chain; collagen, type XI, alpha 2; DFNA13
应用：
WB
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
P13942
规格：
目录价
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Description |
|---|
Poly [ADP-ribose] polymerase 1 (PARP-1) also known as NAD+ ADP-ribosyltransferase 1 or poly[ADP-ribose] synthase 1 is an enzyme that in humans is encoded by the PARP1 gene. PARP1 has a role in repair of single-stranded DNA (ssDNA) breaks. Knocking down intracellular PARP1 levels with siRNA or inhibiting PARP1 activity with small molecules reduces repair of ssDNA breaks. In the absence of PARP1, when these breaks are encountered during DNA replication, the replication fork stalls, and double-strand DNA (dsDNA) breaks accumulate. |
Specification |
|
|---|---|
| Aliases | COBA2; COL11A2; Collagen alpha-2(XI) chain; collagen, type XI, alpha 2; DFNA13 |
| Entrez GeneID | 1302; |
| Swissprot | P13942 |
| WB Predicted band size | 116kDa |
| Host/Isotype | Rabbit IgG |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
|
|---|---|
| WB | 1/1000-1/3000 |
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