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Mouse Monoclonal Antibody to ACTH
货号: 31934
别名: POMC; LPH; MSH; NPP; POC; CLIP
应用: IF,FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: P01189
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Description

This gene encodes a preproprotein that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the preproprotein and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. The antimicrobial melanotropin alpha peptide exhibits antibacterial and antifungal activity. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.

References

1.Tumour Biol. 2015 Mar;36(3):1811-7.
2.J Neurosci. 2013 Feb 20;33(8):3624-32.

Specification

Aliases POMC; LPH; MSH; NPP; POC; CLIP
Entrez GeneID 5443
Swissprot P01189
clone 3A4H4
WB Predicted band size 29.4kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human ACTH expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

IF 1/200 - 1/1000
FCM 1/200-1/400
ELISA 1/10000
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