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Rabbit Polyclonal Antibody to CASR
货号: P43515
别名: CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A; HYPOC1
应用: WB,IHC
反应种属: Human
抗体类型: Primary antibody
Swissprot: P41180
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Description

The protein encoded by this gene is a G protein-coupled receptor that is expressed in the parathyroid hormone (PTH)-producing chief cells of the parathyroid gland, and the cells lining the kidney tubule. It senses small changes in circulating calcium concentration and couples this information to intracellular signaling pathways that modify PTH secretion or renal cation handling, thus this protein plays an essential role in maintaining mineral ion homeostasis. Mutations in this gene cause familial hypocalciuric hypercalcemia, familial, isolated hypoparathyroidism, and neonatal severe primary hyperparathyroidism.

Specification

Aliases CAR; FHH; FIH; HHC; EIG8; HHC1; NSHPT; PCAR1; GPRC2A; HYPOC1
Entrez GeneID 846;
Swissprot P41180
WB Predicted band size 121kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Synthetic protein corresponding to residues near the C terminal of human CASR
Formulation Purified antibody in PBS with 0.05% sodium azide.

Application

WB 1/200-1/1000
IHC 1/ 50-300
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