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Rabbit Polyclonal Antibody to Ataxin-1 (phospho Ser776)
货号: P44616
别名: ATXN1; ATX1; SCA1; Ataxin-1; Spinocerebellar ataxia type 1 protein
应用: WB,IHC,IF
反应种属: Human,Mouse
抗体类型: Primary antibody
Swissprot: P54253
规格:
目录价 ¥2180
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Description

ataxin 1(ATXN1) Homo sapiens The autosomal dominant cerebellar ataxias (ADCA) are a heterogeneous group of neurodegenerative disorders characterized by progressive degeneration of the cerebellum, brain stem and spinal cord. Clinically, ADCA has been divided into three groups: ADCA types I-III. ADCAI is genetically heterogeneous, with five genetic loci, designated spinocerebellar ataxia (SCA) 1, 2, 3, 4 and 6, being assigned to five different chromosomes. ADCAII, which always presents with retinal degeneration (SCA7), and ADCAIII often referred to as the `pure‘ cerebellar syndrome (SCA5), are most likely homogeneous disorders. Several SCA genes have been cloned and shown to contain CAG repeats in their coding regions. ADCA is caused by the expansion of the CAG repeats, producing an elongated polyglutamine tract in the corresponding protein. The expanded repeats are variable in size and unstable, usually increasing in size when transmitted

Specification

Aliases ATXN1; ATX1; SCA1; Ataxin-1; Spinocerebellar ataxia type 1 protein
Entrez GeneID 6310
Swissprot P54253
WB Predicted band size 87kDa
Host/Isotype Rabbit IgG
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human,Mouse
Immunogen The antiserum was produced against synthesized peptide derived from human Ataxin 1 around the phosphorylation site of Ser776. AA range:742-791
Formulation Purified antibody in PBS with 0.05% sodium azide,0.5%BSA and 50% glycerol.

Application

WB 1/500 - 1/2000
IHC 1/100 - 1/300
IF 1/200 - 1/1000
ELISA 1/10000

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