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Mouse Monoclonal Antibody to IGF1R
货号: 32052
别名: IGFR; CD221; IGFIR; JTK13
应用: WB,FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: P08069
规格:
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Description

This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.

References

1,Cells. 2019 Dec 14;8(12):1638.
2,Nature. 2020 Jul;583(7817):615-619.

Specification

Aliases IGFR; CD221; IGFIR; JTK13
Entrez GeneID 3480
Swissprot P08069
clone 3B4E3
WB Predicted band size 154.8kDa
Host/Isotype Mouse IgG2a
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human IGF1R (AA: extra(741-935)) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
FCM 1/200 - 1/400
ELISA 1/10000
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