Mouse Monoclonal Antibody to IGF1R
货号:
32052
别名:
IGFR; CD221; IGFIR; JTK13
应用:
WB,FCM
反应种属:
Human
抗体类型:
Primary antibody
Swissprot:
P08069
规格:
目录价
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Description |
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This receptor binds insulin-like growth factor with a high affinity. It has tyrosine kinase activity. The insulin-like growth factor I receptor plays a critical role in transformation events. Cleavage of the precursor generates alpha and beta subunits. It is highly overexpressed in most malignant tissues where it functions as an anti-apoptotic agent by enhancing cell survival. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. |
References |
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1,Cells. 2019 Dec 14;8(12):1638. 2,Nature. 2020 Jul;583(7817):615-619. |
Specification |
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Aliases | IGFR; CD221; IGFIR; JTK13 |
Entrez GeneID | 3480 |
Swissprot | P08069 |
clone | 3B4E3 |
WB Predicted band size | 154.8kDa |
Host/Isotype | Mouse IgG2a |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Purified recombinant fragment of human IGF1R (AA: extra(741-935)) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application |
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WB | 1/500 - 1/2000 |
FCM | 1/200 - 1/400 |
ELISA | 1/10000 |
Product Image
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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
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Western blot analysis using IGF1R mouse mAb against NIH3T3 (1), cell lysate.
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Flow cytometric analysis of HepG2 cells using IGF1R mouse mAb (green) and negative control (red).
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Flow cytometric analysis of Lovo cells using IGF1R mouse mAb (green) and negative control (red).