Mouse Monoclonal Antibody to CD121B
货号:
32063
别名:
IL1R2;IL1RB; IL1R2c; CDw121b; IL-1R-2; IL-1RT2; IL-1RT-2
应用:
IF,FCM
反应种属:
Human
抗体类型:
Primary antibody
Swissprot:
P27930
规格:
目录价
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Description |
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The protein encoded by this gene is a cytokine receptor that belongs to the interleukin 1 receptor family. This protein binds interleukin alpha (IL1A), interleukin beta (IL1B), and interleukin 1 receptor, type I(IL1R1/IL1RA), and acts as a decoy receptor that inhibits the activity of its ligands. Interleukin 4 (IL4) is reported to antagonize the activity of interleukin 1 by inducing the expression and release of this cytokine. This gene and three other genes form a cytokine receptor gene cluster on chromosome 2q12. Alternative splicing results in multiple transcript variants and protein isoforms. Alternative splicing produces both membrane-bound and soluble proteins. A soluble protein is also produced by proteolytic cleavage. |
References |
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1.Mol Genet Genomic Med. 2019 May;7(5):e644. 2.Mol Genet Genomic Med. 2019 Jan;7(1):e00516. |
Specification |
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Aliases | IL1R2;IL1RB; IL1R2c; CDw121b; IL-1R-2; IL-1RT2; IL-1RT-2 |
Entrez GeneID | 7850 |
Swissprot | P27930 |
clone | 5D7B1 |
WB Predicted band size | 45.4kDa |
Host/Isotype | Mouse IgG1 |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human |
Immunogen | Purified recombinant fragment of human CD121B (AA: extra 14-343) expressed in HEK293-6e cells supernatant. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application |
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IF | 1/50 - 1/200 |
FCM | 1/200 - 1/400 |
ELISA | 1/10000 |
Product Image
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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
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Immunofluorescence analysis of Hela cells using CD121B mouse mAb (green). Blue: DRAQ5 fluorescent DNA dye. Red: Actin filaments have been labeled with Alexa Fluor- 555 phalloidin. Secondary antibody from Fisher (Cat#: 35503)
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Flow cytometric analysis of THP-1 cells using CD121B mouse mAb (green) and negative control (red).