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Mouse Monoclonal Antibody to CD178
货号: 32136
别名: FASLG; APTL; FASL; CD95L; ALPS1B; CD95-L; TNFSF6; TNLG1A; APT1LG1
应用: IF,FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: P48023
规格:
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Description

This gene is a member of the tumor necrosis factor superfamily. The primary function of the encoded transmembrane protein is the induction of apoptosis triggered by binding to FAS. The FAS/FASLG signaling pathway is essential for immune system regulation, including activation-induced cell death (AICD) of T cells and cytotoxic T lymphocyte induced cell death. It has also been implicated in the progression of several cancers. Defects in this gene may be related to some cases of systemic lupus erythematosus (SLE). Alternatively spliced transcript variants have been described.

References

1.Mol Cancer Res. 2019 Dec;17(12):2537-2548.
2.Cell Death Dis. 2018 Jun 11;9(6):695.

Specification

Aliases FASLG; APTL; FASL; CD95L; ALPS1B; CD95-L; TNFSF6; TNLG1A; APT1LG1
Entrez GeneID 356
Swissprot P48023
clone 2A6E12
WB Predicted band size 31.5kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human CD178 (AA: extra 103-281) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

IF 1/50 - 1/200
FCM 1/200 - 1/400
ELISA 1/10000
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