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Mouse Monoclonal Antibody to CD220
货号: 32221
别名: INSR; HHF5
应用: FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: P06213
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Description

This gene encodes a member of the receptor tyrosine kinase family of proteins. The encoded preproprotein is proteolytically processed to generate alpha and beta subunits that form a heterotetrameric receptor. Binding of insulin or other ligands to this receptor activates the insulin signaling pathway, which regulates glucose uptake and release, as well as the synthesis and storage of carbohydrates, lipids and protein. Mutations in this gene underlie the inherited severe insulin resistance syndromes including type A insulin resistance syndrome, Donohue syndrome and Rabson-Mendenhall syndrome. Alternative splicing results in multiple transcript variants.

References

1.Genes (Basel). 2019 Nov 29;10(12):984.
2.Gastric Cancer. 2019 Nov;22(6):1130-1142.

Specification

Aliases INSR; HHF5
Entrez GeneID 3643
Swissprot P06213
clone 1A1G3
WB Predicted band size 156kDa
Host/Isotype Mouse IgG2a
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human CD220 (AA: extra 413-624) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

FCM 1/200 - 1/400
ELISA 1/10000
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