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Mouse Monoclonal Antibody to SORL1
货号: 20164
别名: SORL1
应用:
反应种属: Human
抗体类型: Primary antibody
Swissprot: Q92673
规格:
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Description

SORL1 (sortilin-related receptor, L A repeats containing) also known as sorting protein-related receptor containing LDLR class A (SorLA), is a Type I membrane protein that may be involved in cell-cell interaction. SorLA, a single transmembrane receptor, binds LDL and transports it into cells by endocytosis. SorLA is synthesized as a proreceptor which is processed to the mature form by a furin-like propeptidase. It can also bind to RAP (receptor-associated protein). SorLA is a multifunctional endocytis receptor important in lipoprotein and protease uptake. The N-terminal propeptide, which is removed, can be cleaved by furin or homologous proteases. Endogenous SorLA binds the neuropeptide head activator (HA) and is important for HA signaling and function. The gene encoding for the protein maps to chromosome 8p23.1. SorLA is expressed mainly in brain (cerebral cortex, cerebellum and the occipital pole), but can also be found in liver, spinal cord, kidney, testis and pancreas.

References

1. Scherzer CR. Offe K. Gearing M. et al. Arch Neurol. 2004, Aug, 61(8):1200-5.
2. Gabrielsson BG. Olofsson LE. Sjogren A. et al. Obes Res. 2005, Apr, 13(4):649-52.
3. Shah S. Yu G. Mol Interv. 2006, Apr, 6(2):74-6, 58. Review.

Specification

Aliases SORL1
Entrez GeneID 6653
Swissprot Q92673
clone 7D7B11
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of SORL1 (aa2159-2214) expressed in E. Coli.
Formulation Ascitic fluid containing 0.03% sodium azide.

Application

ELISA 1/10000

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