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Mouse Monoclonal Antibody to XPC
货号: 32369
别名: XP3; RAD4; XPCC; p125
应用: WB,IHC,IF,FCM
反应种属: Human
抗体类型: Primary antibody
Swissprot: Q01831
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Description

The protein encoded by this gene is a key component of the XPC complex, which plays an important role in the early steps of global genome nucleotide excision repair (NER). The encoded protein is important for damage sensing and DNA binding, and shows a preference for single-stranded DNA. Mutations in this gene or some other NER components can result in Xeroderma pigmentosum, a rare autosomal recessive disorder characterized by increased sensitivity to sunlight with the development of carcinomas at an early age. Alternatively spliced transcript variants have been found for this gene.

References

1,Acta Medica (Hradec Kralove). 2020;63(3):101-112.
2,Nat Commun. 2020 Nov 17;11(1):5834.

Specification

Aliases XP3; RAD4; XPCC; p125
Entrez GeneID 7508
Swissprot Q01831
clone 5F4D3
WB Predicted band size 106kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human
Immunogen Purified recombinant fragment of human XPC (AA: 32-133) expressed in mammalian.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

WB 1/500 - 1/2000
IHC 1/200 - 1/1000
IF 1/50 - 1/200
FCM 1/200 - 1/400
ELISA 1/10000
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