Mouse Monoclonal Antibody to MRE11
货号:
32433
别名:
ATLD; HNGS1; MRE11A; MRE11B
应用:
WB,IHC,FCM
反应种属:
Human, Mouse, Monkey, Rat
抗体类型:
Primary antibody
Swissprot:
P49959
规格:
目录价
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Description |
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This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms. |
References |
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Cancer Lett. 2021 Aug 28;514:1-11. Diagn Pathol. 2019 Jun 21;14(1):60. |
Specification |
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Aliases | ATLD; HNGS1; MRE11A; MRE11B |
Entrez GeneID | 4361 |
Swissprot | P49959 |
clone | 7C8A9 |
WB Predicted band size | 80.6kDa |
Host/Isotype | Mouse IgG2b |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse, Monkey, Rat |
Immunogen | Purified recombinant fragment of human MRE11 (AA: 182-582) expressed in E. Coli. |
Formulation | Purified antibody in PBS with 0.05% sodium azide |
Application |
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WB | 1/500 - 1/2000 |
IHC | 1/200 - 1/1000 |
FCM | 1/200 - 1/400 |
ELISA | 1/10000 |
Product Image
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Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)
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Western blot analysis using MRE11 mouse mAb against Hela (1), A431 (2), MCF-7 (3), Jurkat (4), HepG2 (5), K562 (6), COS-7 (7), PC-12 (8) and NIH/3T3 (9) cell lysate.
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Flow cytometric analysis of Hela cells using MRE11 mouse mAb (green) and negative control (red).
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Flow cytometric analysis of K562 cells using MRE11 mouse mAb (green) and negative control (red).
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Immunohistochemical analysis of paraffin-embedded human ovarian cancer tissues using MRE11 mouse mAb with DAB staining.
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Immunohistochemical analysis of paraffin-embedded human rectal cancer tissues using MRE11 mouse mAb with DAB staining.
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Immunohistochemical analysis of paraffin-embedded Mouse testis tissues using MRE11 mouse mAb with DAB staining.
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Immunohistochemical analysis of paraffin-embedded Rat testis tissues using MRE11 mouse mAb with DAB staining.
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Immunohistochemical analysis of paraffin-embedded Rabbit testis tissues using MRE11 mouse mAb with DAB staining.