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Mouse Monoclonal Antibody to MRE11
货号: 32416
别名: ATLD; HNGS1; MRE11A; MRE11B
应用: IHC,FCM
反应种属: Human, Rat
抗体类型: Primary antibody
Swissprot: P49959
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Description

This gene encodes a nuclear protein involved in homologous recombination, telomere length maintenance, and DNA double-strand break repair. By itself, the protein has 3' to 5' exonuclease activity and endonuclease activity. The protein forms a complex with the RAD50 homolog; this complex is required for nonhomologous joining of DNA ends and possesses increased single-stranded DNA endonuclease and 3' to 5' exonuclease activities. In conjunction with a DNA ligase, this protein promotes the joining of noncomplementary ends in vitro using short homologies near the ends of the DNA fragments. This gene has a pseudogene on chromosome 3. Alternative splicing of this gene results in two transcript variants encoding different isoforms.

References

1.Cancer Lett. 2021 Aug 28;514:1-11.
2.Diagn Pathol. 2019 Jun 21;14(1):60.

Specification

Aliases ATLD; HNGS1; MRE11A; MRE11B
Entrez GeneID 4361
Swissprot P49959
clone 4D2B6
WB Predicted band size 80.6kDa
Host/Isotype Mouse IgG1
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species Reactivity Human, Rat
Immunogen Purified recombinant fragment of human MRE11 (AA: 182-582) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

IHC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
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