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Mouse Monoclonal Antibody to ATM
货号: 32439
别名: AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
应用: IHC,FCM
反应种属:
抗体类型: Primary antibody
Swissprot: Q13315
规格:
目录价
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Description

The protein encoded by this gene belongs to the PI3/PI4-kinase family. This protein is an important cell cycle checkpoint kinase that phosphorylates; thus, it functions as a regulator of a wide variety of downstream proteins, including tumor suppressor proteins p53 and BRCA1, checkpoint kinase CHK2, checkpoint proteins RAD17 and RAD9, and DNA repair protein NBS1. This protein and the closely related kinase ATR are thought to be master controllers of cell cycle checkpoint signaling pathways that are required for cell response to DNA damage and for genome stability. Mutations in this gene are associated with ataxia telangiectasia, an autosomal recessive disorder.

References

MC Cancer. 2021 Jan 5;21(1):27.
Fam Cancer. 2022 Apr;21(2):211-227.

Specification

Aliases AT1; ATA; ATC; ATD; ATE; ATDC; TEL1; TELO1
Entrez GeneID 472
Swissprot Q13315
clone 2A7A10
WB Predicted band size 350.7kDa
Host/Isotype Mouse IgG2a
Antibody Type Primary antibody
Storage Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Immunogen Purified recombinant fragment of human ATM (AA: 2577-3056) expressed in E. Coli.
Formulation Purified antibody in PBS with 0.05% sodium azide

Application

IHC 1/200 - 1/1000
FCM 1/200 - 1/400
ELISA 1/10000
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