Rabbit Polyclonal Antibody to CDKN1B
货号:
P00260
别名:
KIP1; MEN4; CDKN4; MEN1B; P27KIP1
应用:
IHC
反应种属:
Human, Mouse
抗体类型:
Primary antibody
Swissprot:
P46527
规格:
目录价
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Description |
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This gene encodes a cyclin-dependent kinase inhibitor, which shares a limited similarity with CDK inhibitor CDKN1A/p21. The encoded protein binds to and prevents the activation of cyclin E-CDK2 or cyclin D-CDK4 complexes, and thus controls the cell cycle progression at G1. The degradation of this protein, which is triggered by its CDK dependent phosphorylation and subsequent ubiquitination by SCF complexes, is required for the cellular transition from quiescence to the proliferative state. Mutations in this gene are associated with multiple endocrine neoplasia type IV (MEN4). |
Specification |
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Aliases | KIP1; MEN4; CDKN4; MEN1B; P27KIP1 |
Swissprot | P46527 |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse |
Immunogen | Fusion protein of human CDKN1B |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
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IHC | 1/50-1/300 |
ELISA | 1/5000-1/10000 |
Product Image
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The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P00260(CDKN1B Antibody) at dilution 1/75. (Original magnification: ×200)
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The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P00260(CDKN1B Antibody) at dilution 1/75. (Original magnification: ×200)