Mouse Monoclonal Antibody to MDM4
货号：
20247
别名：
HDMX; MDMX; MRP1; MDM4
应用：
WB,IHC,IF
反应种属：
Human
抗体类型：
Primary antibody
Swissprot：
O15151
规格：
目录价
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Description |
|---|
MDM4, encodes a 490-amino acid protein containing a RING finger domain and a putative nuclear localization signal. The MDM4 putative nuclear localization signal, which all Mdm proteins contain, is located in the C-terminal region of the protein. The mRNA is expressed at a high level in thymus and at lower levels in all other tissues tested. MDM4 protein produced by in vitro translation interacts with p53 via a binding domain located in the N-terminal region of the MDM4 protein. MDM4 shows significant structural similarity to p53-binding protein MDM2. |
References |
|---|
| 1. Proc Natl Acad Sci U S A. 2002 Dec 24;99(26):16899-903. 2. Cell Cycle. 2004 Apr;3(4):472-8. 3. Biochem Biophys Res Commun. 2005 Jul 8;332(3):702-9. |
Specification |
|
|---|---|
| Aliases | HDMX; MDMX; MRP1; MDM4 |
| Entrez GeneID | 4194 |
| Swissprot | O15151 |
| clone | 2D10F4 |
| WB Predicted band size | 55kDa |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human |
| Immunogen | Purified recombinant fragment of human MDM4 expressed in E. Coli. |
| Formulation | Purified antibody in PBS with 0.05% sodium azide. |
Application |
|
|---|---|
| IHC | 1/200 - 1/1000 |
| IF | 1/200 - 1/1000 |
| ELISA | 1/10000 |
Product Image
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Western blot analysis using MDM4 mouse mAb against Hela (1), A549 (2) and A431 (3) cell lysate.
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Confocal Immunofluorescence analysis of Hela (left) and L-02 (right) cells using MDM4 mouse mAb (green). Red: Actin filaments have been labeled with DY-554 phalloidin.
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Immunohistochemical analysis of paraffin-embedded human cerebra (left) and lung carcinoma (right) tissues, showing nuclear localization with DAB staining using MDM4 mouse mAb.
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Immunohistochemical analysis of paraffin-embedded human Tonsil tissues using MDM4 mouse mAb
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