Mouse Monoclonal Antibody to MAP4K4
货号：
20235
别名：
HGK; NIK
应用：
WB,FCM
反应种属：
Human,Mouse
抗体类型：
Primary antibody
Swissprot：
O95819
规格：
目录价
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Description |
|---|
MAP4K4: mitogen-activated protein kinase kinase kinase kinase 4. The protein encoded by this gene is a member of the serine/threonine protein kinase family. This kinase has been shown to specifically activate MAPK8/JNK. The activation of MAPK8 by this kinase is found to be inhibited by the dominant-negative mutants of MAP3K7/TAK1, MAP2K4/MKK4, and MAP2K7/MKK7, which suggests that this kinase may function through the MAP3K7-MAP2K4-MAP2K7 kinase cascade, and mediate the TNF-alpha signaling pathway. Alternatively spliced transcript variants encoding different isoforms have been identified. |
References |
|---|
| 1. Mol Cell Biol. 2000 Mar;20(5):1537-45. 2. Curr Biol. 2002 Apr 16;12(8):622-31. 3. J Biol Chem. 2007 Mar 16;282(11):7783-9. |
Specification |
|
|---|---|
| Aliases | HGK; NIK |
| Entrez GeneID | 9448 |
| Swissprot | O95819 |
| clone | 3C7B5 |
| Host/Isotype | Mouse IgG1 |
| Antibody Type | Primary antibody |
| Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
| Species Reactivity | Human,Mouse |
| Immunogen | Purified recombinant fragment of MAP4K4 (aa400-500) expressed in E. Coli. |
| Formulation | Ascitic fluid containing 0.03% sodium azide. |
Application |
|
|---|---|
| WB | 1/500 - 1/2000 |
| FCM | 1/200 - 1/400 |
| ELISA | 1/10000 |
Product Image
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Western blot analysis using MAP4K4 mouse mAb against Jurkat (1),PC-12(2), Jurkat (3) ,HepG2(4) lysate.
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Flow cytometric analysis of NIH3T3 cells using MAP4K4 mouse mAb (green) and negative control (red).
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Flow cytometric analysis of K562 cells using MAP4K4 mouse mAb (green) and negative control (red).
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