Rabbit Polyclonal Antibody to GFRA1
货号:
P03985
别名:
GDNFR; RET1L; RETL1; TRNR1; GDNFRA; GFR-ALPHA-1
应用:
WB,IHC
反应种属:
Human, Mouse, Rat
抗体类型:
Primary antibody
Swissprot:
P56159
规格:
目录价
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Description |
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This gene encodes a member of the glial cell line-derived neurotrophic factor receptor (GDNFR) family of proteins. The encoded preproprotein is proteolytically processed to generate the mature receptor. Glial cell line-derived neurotrophic factor (GDNF) and neurturin (NTN) are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. This receptor is a glycosylphosphatidylinositol (GPI)-linked cell surface receptor for both GDNF and NTN, and mediates activation of the RET tyrosine kinase receptor. This gene is a candidate gene for Hirschsprung disease. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed. |
Specification |
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Aliases | GDNFR; RET1L; RETL1; TRNR1; GDNFRA; GFR-ALPHA-1 |
Swissprot | P56159 |
WB Predicted band size | 51 kDa |
Host/Isotype | Rabbit IgG |
Antibody Type | Primary antibody |
Storage | Store at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles. |
Species Reactivity | Human, Mouse, Rat |
Immunogen | Synthetic peptide of human GFRA1 |
Formulation | Purified antibody in PBS with 0.05% sodium azide and 50% glycerol. |
Application |
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WB | 1/500-1/2000 |
IHC | 1/50-1/200 |
ELISA | 1/5000-1/10000 |
Product Image
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Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Rat brain tissue lysate, Primary antibody: P03985(GFRA1 Antibody) at dilution 1/800, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 90 seconds
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The image is immunohistochemistry of paraffin-embedded Human brain tissue using P03985(GFRA1 Antibody) at dilution 1/65. (Original magnification: ×200)
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The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P03985(GFRA1 Antibody) at dilution 1/65. (Original magnification: ×200)